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Question 1 of 30

Which infant is most likely to express Rh incompatibility?

Rationale:
An infant of an Rh-negative mother and a father who is Rh positive and homozygous for the Rh factor is most likely to express Rh incompatibility. This situation guarantees the infant inherits the Rh-positive antigen, triggering the maternal immune system to produce antibodies against the Rh factor, potentially causing hemolytic disease of the newborn due to immune-mediated red blood cell destruction. B: Infant who is Rh negative and a mother who is Rh negative cannot develop Rh incompatibility since both lack the Rh antigen, preventing maternal sensitization or antibody production against Rh-positive red cells. C: Infant of an Rh-negative mother and a heterozygous Rh-positive father has a 50% chance of being Rh positive, lowering the likelihood of Rh incompatibility compared to a homozygous Rh-positive father. D: Infant who is Rh positive and a mother who is Rh positive will not experience Rh incompatibility because the mother’s immune system recognizes the Rh antigen as self, avoiding antibody formation.