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Question 1 of 30

What complication is high risk for women on hormone replacement therapy (HRT) for an extended period?

Rationale:
Endometrial cancer is a high-risk complication for women on hormone replacement therapy (HRT) for an extended period. Prolonged estrogen exposure without adequate progesterone increases endometrial proliferation, raising the likelihood of malignant transformation. This risk is particularly significant in unopposed estrogen therapy, emphasizing the need for balanced hormone regimens to prevent hyperplasia and cancer development in the uterine lining. B: Gynecomastia pertains to male breast tissue enlargement and does not relate to female hormone therapy, making it an irrelevant complication in women undergoing HRT. C: Renal dysfunction is not commonly associated with hormone replacement therapy, as HRT primarily affects reproductive tissues rather than kidney function or structure. D: Mammary hypertrophy refers to breast tissue enlargement but is not a recognized severe risk or complication linked with long-term HRT in women.